The FAST system is capable of recording and displaying chemical activity in the brain, in near real-time, using small microelectrodes connected to a computer via a custom interface box. The system is used by many laboratories around the world for studying brain function and dysfunction during illnesses such as Parkinson's and Alzheimer's diseases.
Software Developed by: Susanne Coates, Ph.D., TechCentric Design Group, LLC. (2003 - 2014)
Languages Utilized: Labview, SQL and PHP.
Hardware developed by: Greg Gerhardt, Ph.D., Quanteon, LLC
System Validation and Testing: Jason Burmeister Consulting, LLC and the University of Kentucky's Center for Microelectrode Technology
There are numerous peer-reviewed articles which use data collected with the system and software. Several recent publications include:
- Dynamic changes in dopamine neuron function after DNSP-11 treatment: Effects in vivo and increased ERK 1/2 phosphorylation in vitro. Fuqua JL, Littrell OM, Lundblad M, Turchan-Cholewo J, Abdelmoti LG, Galperin E, Bradley LH, Cass WA, Gash DM, Gerhardt GA. Peptides. 2014 Jan 7;54C:1-8. doi: 10.1016/j.peptides.2013.12.007. [Epub ahead of print]
- Conformal ceramic electrodes that record glutamate release and corresponding neural activity in primate prefrontal cortex. Hampson RE, Fuqua JL, Huettl PF, Opris I, Song D, Shin D, Marmarelis VZ, Berger TW, Gerhardt GA, Deadwyler SA. Conf Proc IEEE Eng Med Biol Soc. 2013;2013:5954-7. doi: 10.1109/EMBC.2013.6610908.
- Dopamine release from serotonergic nerve fibers is reduced in L-DOPA-induced dyskinesia. Nevalainen N, Af Bjerkén S, Lundblad M, Gerhardt GA, Strömberg I. J Neurochem. 2011 Jul;118(1):12-23.
- In vivo real-time measurement of nitric oxide in anesthetized rat brain. Barbosa RM, Lourenço CF, Santos RM, Pomerleau F, Huettl P, Gerhardt GA, Laranjinha J. Methods Enzymol. 2008; 441:351-67.
- Chronic second-by-second measures of L-glutamate in the CNS of freely moving rats. Rutherford EC, Pomerleau F, Huettl P, Stromberg I and Gerhardt GA. J Neurochem, Feb. 2007.